WordPress 2.6.1 is now available for use. It must be noted, however, that this release is an optional upgrade and is recommended only for self-hosted users who have their blogs on Windows Hosting ( with IIS ). So, if you are one of them, then you must consider upgrading. This is what the WordPress team says about this release fixing a lot of issues for IIS:

For IIS users, 2.6.1 fixes several permalink problems. Image insertion problems in the Press This feature experienced by IE users are also fixed. Of note to everyone is a fix for a performance bug in the admin where those with a lot of plugins would experience slowness on some pages.

It also has some fixes for international users, especially right-to-left languages improvements:

2.6.1 offers several improvements for international users. Styling of the admin for right-to-left languages is much improved thanks to the efforts of the Farsi and Hebrew translation teams, and a mysterious gettext bug caused by certain PHP configurations is now fixed.